Never take them off.
If I am at home, I am wearing my Oofos. Wearing them has significantly reduced my back and leg pain from walking on hardwood floors. My most recent pair was to replace a pair I left at my parents' home so that I could wear them when I visit. The adjustable flap on this version is the way to go, since Oofos in my experience run a bit small. I wear a 9. 5 but buy a 10 and the strap allows me to adjust for comfort and fit. Don't hesitate to try Oofos!